Recombinant Mouse Cd40 Protein(Fc-His tag) (MH0240CL)

Recombinant Mouse Cd40 Protein (P27512) (Met 1-Arg 193) with polyhistidine-tagged Fc region of human IgG1 at the C-terminus was expressed in HEK293.

Datasheet

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PRODUCT INFORMATION

Cat.No.

MH0240CL

Synonyms

CD40; IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5

Accession

Cd40

Predicted N Terminal

Leu 20

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured by its ability to bind recombinant human CD40L in a functional ELISA.

Molecular Mass

Recombinant Mouse CD40/Fc is a disulfide-linked homodimer The reduced monomer comprises 422 amino acids and has a predicted molecular mass of 47 kDa. As a result of glycosylation, it migRates as an approximately 57 kDa band in SDS-PAGE under reducing conditions.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 90 % by SDS-PAGE.

Storage

In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.

Reconstitution

Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.

Warning

For research use only!

Background

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

Tag

Fc-His

Species

Mouse

Source

HEK293

BACKGROUND

Background

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.