Recombinant Antibody Production Services
Background
In the field of biomedical research and drug development, recombinant antibody technology is highly favored due to its high efficiency, high specificity and customizability. Compared with traditional hybridoma antibodies, recombinant antibody technology has shown many unique advantages. Traditional hybridoma technology relies on animal immunization and subsequent cell fusion and screening processes. This process is not only time-consuming, but also has certain uncertainties and repeatability problems due to its reliance on animal immune responses. In contrast, the production of recombinant antibodies is based on known antibody gene sequences, and antibody proteins are directly expressed in host cells through genetic engineering. This method not only eliminates the process of immunizing animals and hybridoma cell screening, but also greatly accelerates the antibody development cycle, making rapid production and mass preparation of antibodies possible. In addition, recombinant antibodies also allow precise editing of antibody sequences to optimize their functional properties, such as improving affinity, improving stability and reducing immunogenicity, providing more flexible and efficient solutions for scientific research and clinical applications.
Recombinant antibodies can not only help researchers gain a deeper understanding of the mechanism of the disease, but also provide a powerful tool for clinical diagnosis and treatment. As a company focusing on biotechnology innovation and recombinant protein/antibody research and development, Profacgen providing customers with high-quality recombinant antibody production services, aiming to provide customized recombinant antibody solutions for academia and industry through advanced genetic engineering technology. The recombinant antibody production services we provide cover a series of links from the cloning of antibody heavy and light chains, optimization of expression systems, antibody expression and purification to quality control of the final product. Our team has rich experience and expertise and can design the most appropriate experimental plan based on the specific needs of customers. Whether it is for basic research or preclinical trials, we will wholeheartedly provide you with efficient and reliable recombinant antibody preparation services.
Service Procedure
Profacgen uses four main expression systems to meet different types of recombinant antibody production needs:
- Mammalian cell expression system: suitable for producing human or humanized antibodies with the correct glycosylation pattern to ensure that the antibodies have good biological activity and pharmacokinetic properties.
- Yeast expression system: For antibody fragments or small antibody molecules that do not require complex post-modification, the yeast system is a cost-effective choice.
- Insect cell expression system: using baculovirus vectors to transfect insect cells, suitable to produce antibodies with complex glycosylation structures.
- E. coli expression system: although it is mainly used to produce non-glycosylated antibody fragments such as Fab or scFv.
Our professional team provides the most suitable production solutions for our clients' diverse needs:
Our Advantages
Our recombinant antibody production services have established an excellent reputation in the industry with a number of core advantages. Here are some of the key advantages we can provide to our customers:
- Advanced genetic engineering technology: Improve the affinity and specificity of antibodies to ensure the quality and efficacy of the final product.
- Diverse expression platforms: With a variety of mature expression systems, including mammalian cells, insect cells, yeast, and E. coli, we can choose the best production method for different types of antibodies and application scenarios.
- Professional technical support team: Provide one-stop service from project consultation to experimental design to data interpretation.
- Strict quality control system: We implement strict quality control measures in every production link
- Quick response and efficient delivery: We have established an efficient internal coordination mechanism to shorten the time cycle from order receipt to product delivery.
Case Study
Core Equipment
Recombinant Antibody Expression Result
