A New Degradable Polymer for Drug Delivering

Compared with the previous small-molecule drugs, protein drugs have the characteristics of high activity, strong specificity, low toxicity, and precise biological functions. They are beneficial to clinical application, so they have become essential for pharmaceutical products. Intracellular delivery of proteins is of great significance for developing protein drugs and basic biological research. Most of the currently reported delivery methods require biological or chemical modification of the delivered protein molecules, which are complicated and unfavorable to maintain their activity. Therefore, it is necessary to find a suitable delivery system to make up for the shortcomings of the drug itself. In recent years, the development of nano-drug delivery systems has emerged as an effective solution to this dilemma. Covalent attachment of polyethylene glycol (PEG) to proteins, or PEGylation, is the most widely used polymer conjugation technique to address the deficiencies of protein-based drug delivery. However, PEG-assisted drug delivery also presents some problems. Long-term use of PEG can lead to the formation of antibodies in some patients, and studies have found that the use of PEG can lead to vacuoles in some organs, although there is no evidence that vacuoles are harmful to the body. Therefore, the development of polymers that can replace PEG has become the focus of optimizing drug delivery.

In recent years, researchers have gradually developed many PEG substitutes. Researchers have solved the problem of instability in protein delivery by replacing PEG with a trehalose sugar polymer. This degradable polymer can effectively alleviate the local vacuoles caused by PEG accumulation. Since trehalose stabilizes proteins, the polymer exhibits better potential than trehalose in this regard. The stability of this new polymer against external temperature and mechanical force facilitates the long-term storage of proteins. It also exhibits extremely high stability to protein drug solutions during long-distance transport. Owing to the great potential exhibited by this polymer in enhancing the pharmacokinetics and storage stability of therapeutic proteins, it may serve as an excellent alternative to PEG in protein delivery.

The Advantages of this platform include:

• Reduced vacuolation caused by the accumulation of PEG
• No toxicity to the body
• Enhance the stability of protein drugs

Potential Applications

• Development of drug delivery materials
• Effect of protein drug therapies

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Reference

1. Silindir Gunay, Mine & Ozer, Yekta & Chalon, Sylvie. (2015). Drug Delivery Systems for Imaging and Therapy of Parkinson's Disease. Current Neuropharmacology. 14. 10.2174/1570159X14666151230124904.