Fc Fusion Protein Production Service

Fc-based fusion proteins are composed of an immunoglobin Fc domain that is directly linked to another peptide, which using genetic engineering and other technologies. So, it is not only retaining the biological activity of functional protein molecules, but also have some antibody properties, such as long-term half-life. Protein or polypeptide drugs are usually fused with FC to improve characters of pharmacokinetics properties, especially prolong the half-life.

Figure 1. Fc-fusions are homodimers in which an Fc domain of an antibody is covalently linked to another protein (Czajkowsky D M, et al. 2012).

There are several benefits that Fc domains fused to polypeptides or other therapeutics:

• Fc fusion protein can greatly increase the molecular weight of active protein or polypeptide and reduce the filtration rate of glomerulus.
• Human Fc fragment can reduce the immunogenicity of the fusion protein
• The recycling mechanism mediated by FcRn (neonatal Fc receptor) can avoid protein degradation
• Fc fusion protein prolongs the half-life of the fusion protein
• Monomeric Fc fusion and dimeric Fc fusion protein can be achieved by Fc segment with genetic engineering.
• Fc fusion helps to purified with protein A or protein G.

Profacgen can provide soluble Fc fusion protein to applicate in various fields, such as immunotherapy, non-clinical fields (flow cytometry, immunohistochemistry), in vitro activity detection and protein microarray detection with the deepening of research. Our services include but are not limited to, N-term or C-term of Fc fused with single peptides, enzymes, antigens, receptors, ligands, cytokines. With our extensive experience in drug delivery study, we can provide our customer with gene synthesis, Fc fusion protein expression, purification and validation. Our expertise guarantees high protein quality, short turnaround time, and the best price in the market!

If you are interested in our services, please feel free to contact us. We are looking forward to cooperating with you.