Recombinant Human TNFRSF9 Protein(Fc-His tag) (HH0084TL)

Recombinant Human TNFRSF9 Protein (Q07011) (Met 1-Gln 186) with polyhistidine-tagged Fc region of human IgG1 at the C-terminus was expressed in HEK293.

Datasheet

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PRODUCT INFORMATION

Cat.No.

HH0084TL

Synonyms

TNFRSF9; ILA; CD137; 4-1BB; CDw137;

Accession

TNFRSF9

Predicted N Terminal

Gln 25

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured by its binding ability in a functional ELISA . Immobilized recombinant mouse 4-1BB Ligand at 20 μg/ml (100 μl/well) can bind human 4-1BB with a linear range of 15.6-500 ng/ml.

Molecular Mass

Recombinant Human 4-1BB/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 409 amino acids and has a calculated molecular mass of 45.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh4-1BB/Fc monomer is approximately 60-65 kDa due to glycosylation.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 95 % by SDS-PAGE.

Storage

In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.

Reconstitution

Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.

Warning

For research use only!

Background

Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Tag

Fc-His

Species

Human

Source

HEK293

BACKGROUND

Background