Recombinant Human GZMB Protein(His tag) (HH0114GL)

Recombinant Human GZMB Protein (P10144) (Met 1-Tyr 247) with a C-terminal polyhistidine tag was expressed in HEK293.

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PRODUCT INFORMATION

Cat.No.

HH0114GL

Synonyms

GZMB; CCPI; CGL 1; CGL1; CSP B; CTSGL1; HLP; SECT; C11; CTLA-1; CSPB; CGL-1; CSP-B; CTLA1;

Accession

GZMB

Predicted N Terminal

Gly 19

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Molecular Mass

Recombinant Human Granzyme B consists of 240 amino acids and has a calculated molecular mass of 27 kDa. As a result of glycosylation, the apparent molecular mass of rhGranzyme B is approximately 36 kDa in SDS-PAGE under reducing conditions.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 97 % by SDS-PAGE.

Storage

In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.

Reconstitution

Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.

Warning

For research use only!

Background

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Tag

His

Species

Human

Source

HEK293

BACKGROUND

Background