Recombinant Human DPP4 Protein (HH0135DL)

Recombinant Human DPP4 Protein (P27487) (Asn 29-Pro 766) with no tag was expressed in HEK293.

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PRODUCT INFORMATION

Cat.No.

HH0135DL

Synonyms

DPP4; DPPIV; ADCP-2; DPP IV; CD26; ADABP; ADCP2; TP103;

Accession

DPP4

Predicted N Terminal

Asn 29

Form

Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GP-AMC). The specific activity is> 2,500 pmoles/min/μg. Using the Octet RED System, the affinity constant (Kd) of human DPP4 bound to Spike (HCoV-EMC/2

Molecular Mass

Recombinant Human DPPIV exists as the mature active form, and consists of 738 amino acids with a predicted molecular mass of 85.4 kDa. The apparent molecular mass of the glycosylated rhDPPIV is approximately 95 kDa in SDS-PAGE under reducing conditions.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 70 % by SDS-PAGE.

Storage

In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.

Reconstitution

Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.

Warning

For research use only!

Background

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Species

Human

Source

HEK293

BACKGROUND

Background