Recombinant Human CD200R1 Protein(Fc-His tag) (HH0180CL)

Recombinant Human CD200R1 Protein (Q8TD46) (Met 1-Leu 266) with polyhistidine-tagged Fc region of human IgG1 at the C-terminus was expressed in HEK293.

Datasheet

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PRODUCT INFORMATION

Cat.No.

HH0180CL

Synonyms

CD200R1; CD200R; HCRTR2; OX2R; MOX2 receptor; MOX2R

Accession

CD200R1

Predicted N Terminal

Ala 27

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose and 5 % mannitol.

Bio-activity

Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200 at 1 μg/ml (100ul/well) can bind human CD200R1 / Fc Chimera with a linear range of 0.12-16 ng/ml.

Molecular Mass

Recombinant Human CD200R1/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 488 amino acids and has a predicted molecular mass of 54.9 kDa. As a result of glycosylation, rh CD200R1/Fc monomer migRates as an approximately 90-100 kDa band in SDS-PAGE under reducing conditions.

Endotoxin

< 1.0 EU per 1 microgram of protein (determined by LAL method).

Purity

> 94 % by SDS-PAGE.

Storage

In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). Avoid repeated freeze/thaw cycles.

Reconstitution

Reconstitute in sterile distilled water to a concentration of 0.1-1.0 mg/mL.

Warning

For research use only!

Background

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.

Tag

Fc-His

Species

Human

Source

HEK293

BACKGROUND

Background